49ers vs. Cardinals Prediction & Odds

49ers vs. Cardinals, 11/21/22 Spread Betting Prediction, Odds & Trends

NFC West rivals meet on Monday Night Football when the Cardinals host the 49ers at 8:15 p.m. ET from Mexico City.

With Colt McCoy likely to start again for Arizona, what’s the best play when it comes to the spread in tonight’s divisional matchup?

Game Matchup & Betting Odds

475 San Francisco 49ers (-10) at 476 Arizona Cardinals (+10); o/u 42.5

8:15 p.m. ET, Monday, November 21, 2022

Estadio Azteca, Mexico City, Mexico

49ers vs. Cardinals Public Betting Information

Our NFL Public Betting Information page indicates that 64% of public bettors are currently backing the Cardinals when it comes to the spread. This information is subject to change throughout the day, however, so be sure to check the link so you’re receiving the most up-to-date public betting data.

San Francisco 49ers DFS Spin

Jimmy Garoppolo completed 19 of 28 pass attempts for 240 yards and rushed five times for three yards and a touchdown in Sunday's 22-16 win over the Chargers. Garoppolo failed to throw for a touchdown for the first time this season, but he punched in a rushing score from one yard out on his third quarterback sneak of the game. The veteran signal-caller has been fairly consistent in 2022 -- contrary to what we've seen in previous years -- and he just got more weapons back from injury following the bye week. Garoppolo's high floor makes him a great bye week fill-in for Week 11 when the 49ers take on the Cardinals next Monday.

Arizona Cardinals DFS Spin

NFL Network's Ian Rapoport reports Colt McCoy "appears set to start" for the Cardinals against the 49ers on Monday. With Kyler Murray still nursing a hamstring injury, McCoy could make his second-straight start for the Cardinals this season. In last week's game against the Rams, the veteran quarterback completed 26-of-36 passes for 238 yards and one touchdown, looking in complete control of the offense while leading the Cardinals to a 27-17 win. Those banking on Murray returning this weekend will need to move quickly to add McCoy before tonight's game. He's a low-end QB2 against a stout 49ers defense that's allowing the 10th fewest passing yards per game in the league (197.9).

49ers vs. Cardinals Betting Trends

Under is 5-1 in the last 6 meetings in Arizona

Under is 13-4 in 49ers last 17 games overall

Over is 4-0 in Cardinals last 4 games overall

Under is 9-1 in Cardinals last 10 Monday games

49ers vs. Cardinals Prediction:

The 49ers are just 1-7-1 against the spread in their last nine meetings with the Cardinals, while the underdog is 6-1-1 at the betting window in the last eight meetings between these divisional rivals. The Cardinals played hard for McCoy last week with Murray on the shelf and while pulling off the outright upset might be difficult, I do see Arizona hanging with San Francisco tonight as a dog.


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