49ers vs. Cardinals Total Prediction

49ers vs. Cardinals, 11/21/22 Monday Night Football Over/Under Prediction

Even though the number only sits at 42.5 points, is the under still the sharp play for tonight’s Monday Night Football matchup between the 49ers and Cardinals at 8:15 p.m. ET from Estadio Azteca in Mexico City?

Game Matchup & Betting Odds

475 San Francisco 49ers (-10) vs. 476 Arizona Cardinals (+10); o/u 42.5

8:15 p.m. ET, Monday, November 21, 2022

Estadio Azteca, Mexico City, Mexico

49ers vs. Cardinals Public Betting Information

Our NFL Public Betting Information page indicates that 64% of public bettors are currently backing the Cardinals when it comes to the spread. This information is subject to change throughout the day, however, so be sure to check the link so you’re receiving the most up-to-date public betting data.

San Francisco 49ers DFS Spin

Christian McCaffrey rushed 14 times for 38 yards and a touchdown while catching four of six targets for 39 yards in Sunday's 22-16 win over the Chargers. McCaffrey struggled to find running lanes against a porous rush defense, but he salvaged what would have been a quiet fantasy day with a short score in the second quarter. Projected 2022 starter Elijah Mitchell (knee) returned from IR in this contest and nearly split touches with his new teammate. Fantasy managers shouldn't worry about Mitchell's presence too much, as McCaffrey still received 18 touches with San Francisco's offense at full strength following the bye. The fantasy stud's managers will enjoy the benefit of a late-matchup scoring boost when the 49ers take on the Cardinals in Mexico City next Monday.

Arizona Cardinals DFS Spin

Kyler Murray (hamstring), who is listed as questionable for Monday's game against the 49ers in Mexico City, appears unlikely to be available to play, Ian Rapoport of NFL Network reports. After sitting out last week's win over the Rams with the hamstring injury, Murray took part in practices Thursday through Saturday, though merely as a limited participant. Cardinals head coach Kliff Kingsbury said Friday that Murray was likely trending toward a game-time call Monday, but as the 8:15 p.m. ET kickoff approaches, the quarterback doesn't look as though he's made enough progress in his recovery to be available. Colt McCoy is thus trending toward another start, with Trace McSorley likely to step in as his backup. Official word on Murray's status will come when Arizona releases its inactive list 90 minutes prior to kickoff.

49ers vs. Cardinals Betting Trends

49ers are 1-7-1 ATS in their last 9 meetings

Road team is 3-1-1 ATS in their last 5 meetings

Underdog is 6-1-1 ATS in their last 8 meetings

49ers are 5-0 ATS in their last 5 vs. NFC West

49ers vs. Cardinals Over/Under Prediction:

The under has been profitable in recent San Francisco games, cashing in 13 of the Niners’ last 17 games overall and in seven of their last nine conference games. The under is also 10-2 in the 49ers’ last 12 games played on grass, is 6-1 in their last seven games when they’re coming off a win and is 5-2 in their last seven games played in the month of November. On the other side, the under is 9-1 in the Cardinals’ last 10 games played on Monday.

MONDAY NIGHT FOOTBALL OVER/UNDER PREDICTION: 49ERS/CARDINALS UNDER 42.5

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