49ers vs. Broncos Prediction & Odds

49ers vs. Broncos, 9/25/22 SNF Betting Predictions, Odds & Trends

The Sunday Night Football matchup for Week 3 in the NFL will feature a non-conference matchup in Denver where the Broncos will host the 49ers at 8:20 p.m. ET.

With the Niners currently listed as 1.5-point road favorites, is the wrong team favored in this matchup?

Game Matchup & Betting Odds

487 San Francisco 49ers (-1.5) at 488 Denver Broncos (+1.5); o/u 43.5

8:20 p.m. ET, Sunday, September 25, 2022

Empower Field at Mile High, Denver, CO

49ers vs. Broncos Public Betting Information

Our NFL Public Betting Information page indicates that 77% of public bettors are currently backing the 49ers when it comes to the spread. This information is subject to change throughout the day, however, so be sure to check the link so you’re receiving the most up-to-date public betting data.

San Francisco 49ers DFS Spin

Jimmy Garoppolo completed 13-of-21 passes for 154 yards and a touchdown in the 49ers' 27-7, Week 2 win over the Seahawks. Garoppolo entered the game on San Francisco's second drive after Trey Lance suffered an ankle injury. Lance was unable to return and a report from ESPN's Adam Schefter says he will miss the remainder of the season. Garoppolo tossed a 38-yard touchdown to backup tight end Ross Dwelley, though most of the yardage came after the catch. In the fourth quarter, Garoppolo snuck in a score at the goal line to ice the game. San Francisco played ultra-conservative in this game, though there was never a need for them to air the ball out. In a more competitive game, Garoppolo could be a viable streaming option. That should be the expectation for the 49ers' Week 3 matchup with Denver.

Denver Broncos DFS Spin

Russell Wilson completed 14-of-31 passes for 219 yards, one touchdown, and one interception in the Broncos' 16-9, Week 2 win over the Texans.  There are many excuses to make: Nathaniel Hackett's clock and red-zone management has been atrocious, Jerry Jeudy was ruled out and KJ Hamler was down, and his remaining receivers dropped plenty of passes. But Wilson drifted in the pocket often, took three sacks, and didn't really have much going beyond Courtland Sutton. The Broncos have now scored 32 points in two games, which we're told is bad for fantasy value. They draw the 49ers on Sunday Night Football next week; it'll be hard to support a QB1 case for Wilson without relying on the preseason priors.

49ers vs. Broncos Betting Trends

Under is 10-3 in Broncos last 13 games overall

Under is 5-2 in Broncos last 7 home games

Under is 5-0 in 49ers last 5 games overall

49ers vs. Broncos Prediction:

The 49ers are 6-1 against the spread in their last seven games overall, are 4-1 against the number in their last five road games and are a perfect 4-0 at the betting window in their last four games following a win. On the other side, the Broncos are just 1-5 against the spread in their last six games overall, are 0-4 against the number in their last four games following a win and are 1-5 at the betting window in their last six games after allowing less than 250 total yards in their previous contest.


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