Colts vs. 49ers SNF Prediction

Colts vs. 49ers, 10/24/21 NFL Week 7 Betting Predictions

The Sunday Night Football matchup for Week 7 is an intriguing one, as the 49ers will look to even their season record against the visiting Colts at 8:20 p.m. ET. With the Niners listed as a 4-point home favorite and the total sitting at 42.5, what’s the best bet for this matchup?

Game Snapshot

471 Indianapolis Colts (+4) at 472 San Francisco 49ers (-4); o/u 42.5

8:20 p.m. ET, Sunday, October 24, 2021

Levi’s Stadium, Santa Clara, CA

TV: NBC

Indianapolis Colts DFS Spin

Carson Wentz completed 11-of-20 passes for 223 yards and two touchdowns in Indianapolis' 31-3 Week 6 victory over the Texans. 103 of the 223 yards came on two deep balls: a 51-yard strike to Parris Campbell for a touchdown, and a 52-yard catch by T.Y. Hilton to set up a field goal. Wentz looked comfortable attacking the Cover-2 seams and busted coverages, but continued to look sluggish under pressure. He will be hard sell QB2 as the Colts take on San Francisco in Week 7.

San Francisco 49ers DFS Spin

Jimmy Garoppolo (calf) will start in Week 7 against the Colts. Garoppolo was removed from San Francisco's final injury report, and with Trey Lance (knee) officially ruled out, will get the nod on Sunday night against Indy. Presumably at full strength post-bye, the only concern for Garoppolo is Santa Clara's current weather report, projecting strong winds and "flooding rain" throughout play. He can still be used as a bye-week filler in deeper leagues if desperate.

Colts vs. 49ers Betting Prediction

The road team has covered in four of the previous five meetings between these two teams, while the Colts are 4-1 against the number in their last five games and 7-2 at the betting window in their last nine road games. On the other side, the Niners are just 1-4 against the spread in their last five games overall, are 1-5 against the number in their last six home games and are 5-22-1 at the betting window in their last 28 games when listed as a home favorite.

NFL WEEK 7 BETTING PREDICTION: SAN FRANCISCO 49ERS -4

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