Rams vs. 49ers Spread Prediction & Odds

Rams vs. 49ers, 10/3/22 Spread Betting Prediction, Odds & Trends

The 49ers have owned the Rams in previous meetings but given the struggles of the San Francisco offense through the first three weeks of the season,

is L.A. the best play when it comes to the spread for tonight’s Monday Night Football matchup at 8:15 p.m. ET?

Game Matchup & Betting Odds

279 Los Angeles Rams (+1.5) at 280 San Francisco 49ers (-1.5); o/u 42.5

8:15 p.m. ET, Monday, October 3, 2022

Levi’s Stadium, Santa Clara, CA

Rams vs. 49ers Public Betting Information

Our NFL Public Betting Information page indicates that 63% of public bettors are currently backing the Rams when it comes to the spread. This information is subject to change throughout the day, however, so be sure to check the link so you’re receiving the most up-to-date public betting data.

Los Angeles Rams DFS Spin

Matthew Stafford completed 18-of-25 passes for 249 yards in the Rams' 20-12, Week 3 win over the Cardinals. The good news is Stafford didn't throw an interception after tossing five across Weeks 1-2, but he also didn't have a touchdown in this one. Cooper Kupp and Allen Robinson both dropped would-be scores, however. The Rams called just 46 offensive plays to Arizona's 81, and Stafford's 25 attempts were his fewest since joining the Rams. Stafford will be a mere QB1/2 next Monday night against the 49ers.

San Francisco 49ers DFS Spin

Deebo Samuel caught 5-of-8 targets for 73 yards in San Francisco's Week 3 loss to Denver, adding five carries for six yards. Deebo was open on wheel routes twice early in the game, once with his quarterback ignoring him, and another time with his quarterback hanging up the ball so long that it likely cost him at least 20 extra receiving yards. Samuel also took a pounding in the middle of the field in the second quarter when he was stood up by the defense and pushed around in a pile by both sides -- he briefly left the game over this. Samuel's last target was a ball thrown wildly behind him by Garoppolo. He's still a lock-and-load WR2 vs. the Rams in Week 4, but he'll need more from his quarterback to play up to his standard.

Rams vs. 49ers Betting Trends

Road team is 5-2 ATS in their last 7 meetings

Under is 7-2 in the last 9 meetings in San Francisco

Under is 4-1 in the last 5 meetings

Underdog is 7-0 ATS in their last 7 meetings

Rams vs. 49ers Prediction:

The Rams are winless against the spread in their last five games versus the 49ers and are 2-5 against the number in their last seven games in San Francisco. The Rams have also dropped four of their last five games ATS overall, are 0-4 against the number in their last four games when playing in Week 4 and have dropped eight of their last 11 games ATS when facing an opponent with a losing record. The 49ers, meanwhile, are 5-0 against the spread in their last five home games, are 6-1 against the number in their last seven conference games and have covered in five of their last six games coming off a loss.

NFL WEEK 4 PREDICTION: SAN FRANCISCO 49ERS -1.5

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