Louisville vs. Kentucky Prediction & Odds

Louisville vs. Kentucky 11/26/22 Betting Prediction, Odds & Trends

Number twenty-five Louisville heads to Lexington to face unranked Kentucky at 3:00 PM ET on Saturday. Can the Cardinals cover the spread as 3-point road underdogs?

Louisville is 7-4 on the year, with their best wins coming against UCF and Wake Forest. Their worst losses came against Syracuse and Boston College. The Cardinals are 7-4 ATS on the year. 

Kentucky is 6-5 on the season with their best wins coming against Florida and Mississippi State. Their worst losses came against South Carolina and Vanderbilt. The Wildcats are 7-4 ATS on the year.

Game Matchup and Betting Odds

159 Louisville Cardinals (+3) at 160 Kentucky Wildcats (-3); O/U 43 

3:00 PM ET Saturday, November 26th, 2022

Kroger Field, Lexington, KY

Louisville vs. Kentucky Public Betting Information

The public favors the Cardinals in this game. Our CFB Public Betting Page shows that 57% of public bets are on Louisville +3. Do note that those numbers are subject to change and could be different once game time rolls around. 

Louisville Game Notes

Louisville dual-threat quarterback Malik Cunningham missed last week’s game against NC State due to a shoulder injury and he’s officially listed as questionable for this week’s game. Louisville head coach Scott Satterfield said he feels “pretty optimistic” that Malik Cunningham will be able to play on Saturday. If for some reason Cunningham can’t go, Louisville will turn to junior QB Brock Domann. Domann threw for 153 yards while completing 48% of his passes in Louisville’s 25-10 win over NC State on Saturday.

Louisville linebacker Yasir Abdullah leads the ACC with 8 sacks on the year. The senior from Miramar, Florida has also recorded 53 total tackles, 4 forced fumbles, 2 interceptions, and 4 passes defended on the campaign. He’ll probably need to excel if Louisville is going to cover this contest.   

Kentucky Game Notes               

Kentucky has two future NFL players in their backfield in quarterback Will Levis and running back Chris Rodriguez. Levis is a 6’3” 232-pound senior with the tools to be a starting quarterback at the next level. This year he’s thrown for 2,218 yards, 17 touchdowns, and 10 interceptions while also adding 2 rushing touchdowns. Levis posted a shining QBR of 86.7 out of 100 in Kentucky’s 16-6 loss to Georgia last week, proving that he can play against the best defenses in the country.

Kentucky’s Chris Rodriguez has run for 784 yards and 6 touchdowns in only 7 games of action this season. That averages out to 112 rushing yards per game. Because he missed the first month of the season, Rodriguez has only carried the ball 152 times this year compared to 205 last year. Chris Rodriguez should get 15+ carries in his final home game and he has a real chance to gain over 100 yards in a game for the 5th time this season. 

Louisville vs. Kentucky Betting Trends

Louisville is 1-6 ATS in their last 7 games against the SEC.

Kentucky is 12-3-1 ATS in their last 16 non-conference games.

Kentucky is 4-1 ATS in their last 5 games against the ACC.

Louisville is 1-4 ATS in their last 5 games against Kentucky.

Louisville vs. Kentucky Betting Prediction

Kentucky began the year 4-0 but then dropped 5 of their next 7 games. They’ve been all over the map this year, beating Florida and Mississippi State when those teams were ranked and then losing to South Carolina and Vanderbilt at home. Then last week Kentucky gave Georgia a game, losing only 16-6 in a contest where they were 22.5-point underdogs. Will Levis and Chris Rodriguez combined to run for 234 yards and 5 touchdowns against Louisville last year, and I think the two seniors end their Kentucky careers in style with a definitive win over their in-state rivals on Saturday.


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